Heterobicyclic oxazolo pyrimidinone are important class of compounds.
They may become promising candidates for exploiting more useful
therapeutically active molecules. The compounds having oxazolo
pyrimidinone moiety are associated with interesting wide spectrum
biological activities, such as antibacterial, kinase inhibition,
adenosine receptor antagonism, tumour growth inhibition and some show to
inhibit the ability of ricin to inactivate the ribosomes etc. The
intermediate azlactones are also useful precursors for the synthesis of
amino acids, peptides, heterocycles, biosensors and antitumor or
antimicrobial compounds. In the present study, it was proposed to
synthesize lead molecules of oxazolo pyrimidinone skeleton, apt for
binding to the target enzyme, bacterial MurB based on the rational
approach and to study their docking simulations using ArgusLab 4.0.1 and
AutoDock 4.2 softwares. The synthesized test compounds were then
characterized by TLC, melting point determination, UV, IR, 1H-NMR and
mass spectral studies and tested for their antibacterial activity and
compare with the standard drug.