This is an exciting era in medicine and in science. Successive waves of
advance in knowledge gather, break and recede uncovering fresh
challenges and new opportunities. Each plays its part in eroding the
tidemark of yesterday's ignorance. Many involved in the day-to-day
management of patients, ill- prepared and ill-equipped by the training
which they received as under- graduate students, find it difficult to
retain contact with the advances in medical science and feel
uncomfortable on the shifting sands of uncertainty upon which we now
stand. Which of the new ideas is sound ? Upon which data may we rely?
How may we distinguish the real from the unreal, the true from the
false, recent advances from recent retreats? These are the anxieties,
often either unstated or alternatively expressed in terms of an attitude
of total opposition to 'all of this research rubbish' which are
widespread in medical circles today. It is for these individuals who are
not themselves directly involved in the immunology of rheumatic diseases
but who, nevertheless, recognize the importance of this subject to their
patients and, in particular, to tomorrow's patients, that this book has
been written. There are two points that I believe to be of central
concern. Firstly, I think it important to recognize that the
intellectual basis of most of the research work being generated today is
actually extremely simple.