It has become increasingly evident within the last few decades that
immunologic factors are involved in some aspects of the reproductive
process and hence in the physiology and pathology of the genital tract.
The concept that immune phenomena participate in human reproduction is
not new. There are examples throughout the history of man that immune
phenomena may have influenced the reproductive process. For example, the
Bible states that Sarah was sterile for a long time but conceived in the
later years of her marriage. This could be interpreted to mean that
continued exposure to her husband's ejaculated antigens re- sulted in
antibody response, sufficient to induce sterility. However, after
continence of long duration, the antibody level declined and conception
became possible. Another of speculation is Darwin's Descent of Man,
which contains a number of state- source ments to the effect that
profligacy of women may account for their "small fertility". The
inference is that repeated exposure to antigenic material in the
ejaculate causes antibody responses that lead to infertility (KATSH and
KATSH, 1965). This is directly related to the modern postulate that
prostitutes do not conceive because of antisperm antibodies acquired by
frequent contact with semen.