How Proteins Work is an up-to-date and authoritative account of
protein function in living systems, explained within the governing
parameters of physics, chemistry, and evolution. This text will enable
advanced undergraduate students in biochemistry and biophysics to
understand the relationships among protein function, structure, and
dynamics. It will also serve as a valuable resource for graduate
students and researchers looking for a reference on the fundamentals
underlying protein function.
By providing an integrated view of proteins at both a cellular and
systemic level, this textbook shows how evolution drives proteins to
adopt domain structures that combine to achieve biological outcomes. The
association of proteins into dimers, molecular machines, and
multi-enzymatic complexes enables them to achieve catalytic and
functional efficiency.