Histocompatibility Antigens: Structure and Function (Softcover Reprint of the Original 1st 1982)Paperback - Softcover Reprint of the Original 1st 1982, 13 November 2013

Histocompatibility Antigens: Structure and Function (Softcover Reprint of the Original 1st 1982)
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Part of Series
World Crop
Print Length
246 pages
Language
English
Publisher
Springer
Date Published
13 Nov 2013
ISBN-10
940095896X
ISBN-13
9789400958968

Description

The Major Histocompatibility Complex (MHC) was discovered as a con- sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans- planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.

Product Details

Book Edition:
Softcover Reprint of the Original 1st 1982
Book Format:
Paperback
Country of Origin:
NL
Date Published:
13 November 2013
Dimensions:
22.86 x 15.24 x 1.4 cm
ISBN-10:
940095896X
ISBN-13:
9789400958968
Language:
English
Location:
Dordrecht
Pages:
246
Publisher:
Springer
Series:
Weight:
358.34 gm

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