Sanjeev Kumar Shukla

(Author)

Heam Polymerization and Its Inhibition by Antimalarial DrugPaperback, 14 March 2012

Heam Polymerization and Its Inhibition by Antimalarial Drug
Qty
1
Turbo
Ships in 2 - 3 days
In Stock
Free Delivery
Cash on Delivery
15 Days
Free Returns
Secure Checkout
Buy More, Save More
Turbo Shipping
Print Length
64 pages
Language
English
Publisher
LAP Lambert Academic Publishing
Date Published
14 Mar 2012
ISBN-10
3848433974
ISBN-13
9783848433971

Description

Malaria is one of the most common diseases in developing countries and poses a great challenge to world health. Resistance of malaria parasites to available antimalarial drugs remains the main challenge to the effective control of the disease. The physiological conditions prevailing with in the acidic digestive vacuoles of the malaria parasites provide a suitable physiochemical environment for conversion of heam to beta-hematin/hemozoin. Though the both protein as well as lipids mediated beta-hematin formation remain valid hypothesis but later seems to be more relevant, when mechanism of hemozoin synthesis is considered as a simple physiochemical reaction. Some repeats earlier heme show loss of beta-hematin formation activity of the parasite lysate by protenase K and heat treatment. The digestion of this cytosol, which consists essentially of hemoglobin results in the formation of potentially toxic ferriprotoporphyrin IX (FP). Several antimalarial drugs are thought to exert their effect by complexing with FP, thus inhibiting its detoxification through polymerization to hemozoin. Our aim shows that inhibition of heam polymerization by Arteether.

Product Details

Authors:
Sanjeev Kumar ShuklaRamesh ChandraS K Puri
Book Format:
Paperback
Country of Origin:
US
Date Published:
14 March 2012
Dimensions:
22.86 x 15.24 x 0.38 cm
ISBN-10:
3848433974
ISBN-13:
9783848433971
Language:
English
Location:
Saarbrucken
Pages:
64
Weight:
104.33 gm

Need Help?
+971 6 731 0280
support@gzb.ae

About UsContact UsPayment MethodsFAQsShipping PolicyRefund and ReturnTerms of UsePrivacy PolicyCookie Notice

VisaMastercardCash on Delivery

© 2024 White Lion General Trading LLC. All rights reserved.