In Glutamate and Addiction, world-renowned scientific experts critically
review all of the evidence for the role of glutamatergic systems in
opiate, stimulant, and alcohol addiction. Using a variety of
pharmacological, biochemical, genetic, and brain imaging techniques,
these investigators show precisely how glutamate affects such addictions
and how modifying certain elements of the glutamatergic system appear to
alleviate particular components of addiction. Their survey takes in both
clinical approaches using medications that influence glutamate and
cutting-edge preclinical approaches that manipulate specific subtypes of
glutamate receptors or specific substrates of the "glutamate cascade" to
determine their roles in various addictive states.