Genomes 5 has been completely revised and updated. It is a thoroughly
modern textbook about genomes and how they are investigated. As with
previous Genomes editions, techniques come first, then genome
anatomies, followed by genome function, and finally genome evolution.
The genomes of all types of organism are covered: viruses, bacteria,
fungi, plants, and animals, including humans and other hominids.
Genome sequencing and assembly methods have been thoroughly revised to
include new developments in long-read DNA sequencing. Coverage of genome
annotation emphasizes genome-wide RNA mapping, with CRISPR-Cas 9 and
GWAS methods of determining gene function covered. The knowledge gained
from these techniques forms the basis of the chapters that describe the
three main types of genomes: eukaryotic, prokaryotic (including
eukaryotic organelles), and viral (including mobile genetic elements).
Coverage of genome expression and replication is truly genomic,
concentrating on the genome-wide implications of DNA packaging,
epigenome modifications, DNA-binding proteins, non-coding RNAs,
regulatory genome sequences, and protein-protein interactions. Also
included are examples of the applications of metabolomics and systems
biology. The final chapter is on genome evolution, including the
evolution of the epigenome, using genomics to study human evolution, and
using population genomics to advance plant breeding. Established methods
of molecular biology are included if they are still relevant today and
there is always an explanation as to why the method is still important.
Genomes 5 is the ideal text for upper-level courses focused on genomes
and genomics.
Key Features
- A highly accessible and well-structured book with chapters organized
into four parts to aid navigation
- Superb artwork illustrates the key concepts and mechanisms
- Each chapter has a set of short-answer questions and in-depth problems
to test the reader's understanding of the material
- Thoroughly up to date with references to the latest research from the
2020s
