Orthodontics, the oldest discipline of dental specialty concerns with
the treatment of malocclusion both dental and skeletal. Although
etiology of malocclusion is multifactorial, genes do have influence on
this condition, beside their role in mechanism of tooth movement and
unwanted sequel like external root resorption following orthodontic
treatment. This short communication will focus the issue on role of gene
in various conditions which have paramount effect either on the etiology
of malocclusion or mechanism by which tooth movement occurs. Human
genome project and future advancement in genomic medicine will help us
in clear identification of conditions causing mutation and the unsolved
zigzag puzzle of molecular interaction can be solved.