This book deals with combinatorial aspects of epistasis, a notion that
existed for years in genetics and appeared in the ?eld of evolutionary
algorithms in the early 1990s. Even thoughthe?rst
chapterputsepistasisintheperspective ofevolutionary algorithms and
arti?cial intelligence, and applications occasionally pop up in other
chapters, thisbookisessentiallyaboutmathematics,
aboutcombinatorialtechniques to compute in an e?cient and mathematically
elegant way what will be de?ned as normalized epistasis. Some of the
material in this book ?nds its origin in the PhD theses of Hugo Van Hove
[97] and Dominique Suys [95]. The sixth chapter also contains
material that appeared in the dissertation of Luk Schoofs [84].
Together with that of M. Teresa Iglesias [36], these dissertations
form the backbone of a decade of mathematical ventures in the world of
epistasis. The authors wish to acknowledge support from the Flemish Fund
of Scienti?c - search (FWO-Vlaanderen) and of the Xunta de Galicia. They
also wish to explicitly
mentiontheintellectualandmoralsupporttheyreceivedthroughoutthepreparation
of this work from their family and their colleagues Emilio Villanueva,
Jose Mar´a Barja and Arnold Beckelheimer, as well as our local T T Xpert
Jan Adriaenssens.