This fourth edition presents an updated and expanded text and
illustrations to reflect continued morphologic, immunophenotypic, and
especially molecular advances in the field of neoplastic hematology,
mostly due to the rapidly expanding application of next-generation
sequencing. Those advances not only allow a more reliable diagnosis of
the majority of tumors and identification of early changes such as
monoclonal B-cell lymphocytosis or clonal hematopoiesis of indeterminate
potential (CHIP), but also in many cases identify mutations or
phenotypic changes in tumors that can be targeted by mutation-specific
or antigen-specific drugs.
This edition incorporates the updated WHO classification of
hematopoietic tumors and new immunophenotypic and molecular markers to
provide a thorough pathologic overview of hematologic neoplasms while
focusing on flow cytometric features. Special emphasis has been put on
hematological neoplasms with crucial clinical significance such as acute
promyelocytic leukemia, other acute leukemias, and difficult areas in
flow cytometry. Flow cytometric features in AML, MDS, CMML, CLL and
measurable residual disease were significantly expanded. There are many
new comparative tables, illustrations, and diagrams of algorithmic
approaches.
