The mercurial diuretic salyrgan produced 3 distinct types of reduction
in renal blood flow and glomerular filtration. The reduction in
glomerular filtration and renal plasma flow produced by hemorrhage or
clamping ofthe aorta above the renal arteries resulted in a marked
decrease in.the e: ffectiveness of the mercurial as a diuretic. The
reduction in glome- rular filtration is probably the more important
factor in this refractori- ness to the mercurial. In the light of these
findings and others brought out in the discussion, the refriwtory state
of the kidney to mercurial diuretics has been discussed. Bibliography. 1
WALKER, A. M., C. F. ScaMIDT, L. A. ELSON and C. G. JoHNSTON: Amer. 2 J.
Physiol. 118, 95 (1937).- SMITH, H. W.: The Kidney, Structure and
Function in Health and disease. New York: Oxford University Press 1951.
Page 892. - 4 3 MoELLER, K. 0.: Arch. exper. Path. u. Pharmakol. 148, 67
(1930). - FARAH, 5 A., and G. MARESH: J. of Pharmacol. 92, 73 (1948). -
DuGGAN, J. J., and R. F.