Environmental Epigenomics in Health and Disease: Epigenetics and Disease Origins (2013)Hardcover - 2013, 29 May 2013

Environmental Epigenomics in Health and Disease: Epigenetics and Disease Origins (2013)
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Part of Series
Epigenetics and Human Health
Print Length
302 pages
Language
English
Publisher
Springer
Date Published
29 May 2013
ISBN-10
3642233791
ISBN-13
9783642233791

Description

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Product Details

Book Edition:
2013
Book Format:
Hardcover
Country of Origin:
NL
Date Published:
29 May 2013
Dimensions:
24 x 16.13 x 2.29 cm
Genre:
Medical/Medicine Aspects
ISBN-10:
3642233791
ISBN-13:
9783642233791
Language:
English
Location:
Berlin, Heidelberg
Pages:
302
Publisher:
Springer
Weight:
585.13 gm

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