As part of its scientific activities, the German Research Council on
Smoking and Health regularly provides opportunities for scientists to
discuss progress in the field of nicotine research. In this context, the
Research Council sponsored a Satellite Symposium in Hamburg, June 28-30,
1990 entitled "Effects of Nicotine on Biological Systems". This meeting
was held in conjunction with the XIth International Congress of
Pharmacology in Amsterdam and follows the first Satellite Symposium on
Nicotine which was convened in Brisbane, Australia in 1987. The aim of
these conferences has been to discuss state of the art research on the
pharmacology and toxicology of nicotine and its metabolites and to
integrate this information to help define nicotinic actions on the
central and peripheral nervous system as well as to evaluate health or
behavioral effects associated with use of this alkaloid. Furthermore, at
this conference, potential therapeutic benefits of nicotine for certain
disease states were discussed. Smoking and the health effects of smoking
were dealt with only as far as they could not be separated from the
effects of nicotine. This volume contains the lectures presented at the
symposium and illustrates that knowledge of nicotine has advanced
considerably in recent years with regard to mechanisms of its actions.
Despite such progress however, it is apparent that a' large number of
questions remain unanswered, especially in the light of new insight into
cellular and molecular mechanisms which can be affected by nicotine.