Drug dosage in renal insufficiency has become an toxication. In 1975,
his Poison Index was pub- important facet of nephrology, a subspeciality
of lished, first in German, and two years later in internal medicine
which is only 30 years young but English, with supplements in 1979 and
1983. This constantly growing in scope and importance. Two- volume has
become an obligatory reference in more thirds of all drugs are
partially, mainly, or exclu- than 2500 dialysis units. sively excreted
by the kidneys. In the presence of Based on GOnter Seyffart's experience
and renal insufficiency, dose adjustments are therefore knowledge in
this field, the plans for this book obligatory. In patients on dialysis,
drug elimination matured in 1984, a logical step in view of his by this
route must also be considered. untiring effort and diligence. In order
to deal with As the reader of this book will discover, 20 more than 1200
different drugs and almost 4000 percent of currently used drugs are
contraindicated references, 21 contributors were sollicited, while it
where there is any degree of renal insufficiency, took six years to
complete the work. The major and for at least another 60 percent a dose
reduc- share of the effort was thus left to the main author tion is
required. It is obvious, therefore, that the and editor and he has
produced a concise work of detailed knowledge required can never be com-
impressive clarity.
