Takashi Daimon

(Author)

Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice (2019)Paperback - 2019, 31 May 2019

Dose-Finding Designs for Early-Phase Cancer Clinical Trials: A Brief Guidebook to Theory and Practice (2019)
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Part of Series
Springerbriefs in Statistics
Part of Series
Springerbriefs in Statistics / Jss Research Series in Statis
Part of Series
Jss Research Series in Statistics
Part of Series
Jss Research Statistics
Print Length
133 pages
Language
English
Publisher
Springer
Date Published
31 May 2019
ISBN-10
4431555846
ISBN-13
9784431555841

Description

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

Product Details

Authors:
Takashi DaimonAkihiro HirakawaShigeyuki Matsui
Book Edition:
2019
Book Format:
Paperback
Country of Origin:
NL
Date Published:
31 May 2019
Dimensions:
23.39 x 15.6 x 0.84 cm
ISBN-10:
4431555846
ISBN-13:
9784431555841
Language:
English
Location:
Tokyo
Pages:
133
Publisher:
Weight:
222.26 gm

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