Understanding the dopamine transporter can lead to new therapies for
neurological disorders
This book consolidates current information on the dopamine transporter
(DAT) in relationto medicinal chemistry and synthesis, biology and
pathology, and pharmacology. Because of DAT's role in diseases such as
Parkinson's, schizophrenia, attention deficit hyperactivity disorder
(ADHD), Tourette syndrome, and drug abuse (in particular, cocaine
addiction), DAT research is an exploding field. Tremendous advances have
been made toward understanding how it impacts a variety of neurological
disease states and disorders.
This reference provides a broad overview of current knowledge that is
detailed enough to furnish a basic understanding of the biological,
chemical, and pharmacological aspects of DAT in one comprehensive
reference. With contributions from eminent scientists who are experts in
their particular areas, Dopamine Transporters: Chemistry, Biology, and
Pharmacology
- Reviews current studies and research in the areas of DAT function,
pathological conditions, cloning, molecular structure, and
electrochemical characterization
- Covers findings in the medicinal chemistry of DAT-inhibitory ligands
and substrates, discussing the chemical syntheses and summarizing the
various structure-activity relationships of important classes of
dopamine uptake inhibitors and dopamine releasers
- Has chapters that focus on technologies for future DAT study,
including imaging and in vivo and in vitro methods
This is a hands-on reference for researchers, medicinal chemists,
pharmacologists, and biologists working with DAT or related proteins and
for students in related areas of study.
