A comprehensive look at existing technologies and processes for
continuous manufacturing of pharmaceuticals
As rising costs outpace new drug development, the pharmaceutical
industry has come under intense pressure to improve the efficiency of
its manufacturing processes. Continuous process manufacturing provides a
proven solution. Among its many benefits are: minimized waste, energy
consumption, and raw material use; the accelerated introduction of new
drugs; the use of smaller production facilities with lower building and
capital costs; the ability to monitor drug quality on a continuous
basis; and enhanced process reliability and flexibility. Continuous
Manufacturing of Pharmaceuticals prepares professionals to take
advantage of that exciting new approach to improving drug manufacturing
efficiency.
This book covers key aspects of the continuous manufacturing of
pharmaceuticals. The first part provides an overview of key chemical
engineering principles and the current regulatory environment. The
second covers existing technologies for manufacturing both
small-molecule-based products and protein/peptide products. The
following section is devoted to process analytical tools for
continuously operating manufacturing environments. The final two
sections treat the integration of several individual parts of processing
into fully operating continuous process systems and summarize
state-of-art approaches for innovative new manufacturing principles.
- Brings together the essential know-how for anyone working in drug
manufacturing, as well as chemical, food, and pharmaceutical
scientists working on continuous processing
- Covers chemical engineering principles, regulatory aspects, primary
and secondary manufacturing, process analytical technology and
quality-by-design
- Contains contributions from researchers in leading pharmaceutical
companies, the FDA, and academic institutions
- Offers an extremely well-informed look at the most promising future
approaches to continuous manufacturing of innovative pharmaceutical
products
Timely, comprehensive, and authoritative, Continuous Manufacturing of
Pharmaceuticals is an important professional resource for researchers
in industry and academe working in the fields of pharmaceuticals
development and manufacturing.
