Aslak Tveito

(Author)

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (2016)Hardcover - 2016, 20 April 2016

Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models (2016)
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Part of Series
Lecture Notes in Computational Science and Engineering
Print Length
261 pages
Language
English
Publisher
Springer
Date Published
20 Apr 2016
ISBN-10
3319300296
ISBN-13
9783319300290

Description

Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the effect of a given drug can be reflected by changing the Markov model. These lecture notes provide an accessible introduction to the mathematical methods needed to deal with these models. They emphasize the use of numerical methods and provide sufficient details for the reader to implement the models and thereby study the effect of various drugs. Examples in the text include stochastic calcium release from internal storage systems in cells, as well as stochastic models of the transmembrane potential. Well known Markov models are studied and a systematic approach to including the effect of mutations is presented. Lastly, the book shows how to derive the optimal properties of a theoretical model of a drug for a given mutation defined in terms of a Markov model.

Product Details

Authors:
Aslak TveitoGlenn T Lines
Book Edition:
2016
Book Format:
Hardcover
Country of Origin:
NL
Date Published:
20 April 2016
Dimensions:
23.39 x 15.6 x 1.75 cm
ISBN-10:
3319300296
ISBN-13:
9783319300290
Language:
English
Location:
Cham
Pages:
261
Publisher:
Weight:
580.6 gm

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