Molecular modeling techniques have been widely used in drug discovery
fields for rational drug design and compound screening. Now these
techniques are used to model or mimic the behavior of molecules, and
help us study formulation at the molecular level. Computational
pharmaceutics enables us to understand the mechanism of drug delivery,
and to develop new drug delivery systems.
The book discusses the modeling of different drug delivery systems,
including cyclodextrins, solid dispersions, polymorphism prediction,
dendrimer-based delivery systems, surfactant-based micelle, polymeric
drug delivery systems, liposome, protein/peptide formulations, non-viral
gene delivery systems, drug-protein binding, silica nanoparticles,
carbon nanotube-based drug delivery systems, diamond nanoparticles and
layered double hydroxides (LDHs) drug delivery systems.
Although there are a number of existing books about rational drug design
with molecular modeling techniques, these techniques still look
mysterious and daunting for pharmaceutical scientists. This book fills
the gap between pharmaceutics and molecular modeling, and presents a
systematic and overall introduction to computational pharmaceutics. It
covers all introductory, advanced and specialist levels. It provides a
totally different perspective to pharmaceutical scientists, and will
greatly facilitate the development of pharmaceutics. It also helps
computational chemists to look for the important questions in the drug
delivery field.
This book is included in the Advances in Pharmaceutical Technology
book series.
