The new edition of this atlas integrates all significant advances made
in the past 15 years in molecular pathology, tumor virology, and
genetics of cervical cancer. It emphasizes the importance of these
advances in facilitating its pathological diagnosis and in op- mizing
clinical management and prognosis. A new chapter on immunohistochemistry
has been added, which includes refined detection methods, e. g., the
overexpression of INK4a p16 as a molecular marker in the early
differential diagnosis of premalignant - sions. The section on etiology
and pathogenesis in human papillomavirus-induced neoplasia has been
incorporated to represent new insights into the sequences of cel- lar
and nuclear deregulation at the molecular level. All chapters have been
revised to - clude the newest advances and relevant experiences in how
to interpret and manage cervical disease; they are supported by the
addition of 35 new microphotographic ill- trations. The tumor
nomenclature is adapted to the latest edition of the WHO classi- cation;
the morphology code of the international classification of diseases for
oncology (ICD-O) has been added. We have also updated the list of
references by adding recent relevant publications. Again, the staff of
Springer-Verlag deserve our thanks for their patience and skill in
preparing the manuscript and in reproducing the microphotographs.
Heidelberg, February 2005 Gisela Dallenbach-Hellweg, Magnus von Knebel
Doeberitz, and Marcus J. Trunk Heading2 Preface to the First Edition
During the past decade our understanding of the histopathology of the
cervix uteri has changed gr
