The- first meeting of the cardiovascular drug therapy forum took place
on April 13-15, 1988 in Montreux, Switzerland. In this meeting, which
was closed to the public, approximately 150 leading investigators in the
field of cardiovascular drug therapy, both academics and from the
pharmaceutical industry, discussed the state of the art and future
trends of this rapidly expanding field. The discussions concentrated on
four major topics: (1) ischemic heart disease; (2) heart failure; (3)
hyper- tension; (4) arrhythmias. These topics were discussed by four
committees in parallel, and thereafter the main points were reviewed by
the whole forum. This framework allowed both intensive and
interdisciplinary discussions. This book, the first publication of
selected topics from the meeting, focuses mainly on nitrate therapy in
ischemic heart disease and heart failure. Adam Schneeweiss, MD Chairman
v Contents Opening Remarks . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 1 Presentation of the Sir Thomas
Lauder Brunton Award for Outstanding Nitrate Research . . . . . . . . .
. . . . . . . . . . . . . . . . . 3 Origins of Symptoms in Heart
Failure - Relevance in Evaluation of New Drugs . . . . . . . . . . . . .
. . . . . . . 5 Mononitrates in Congestive Heart Failure . . . . . . . .
. . . . . . . . . 9 Are There Differences Between the Various
Formulations of Nitrates in Heart Failure? . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 11 Long-Term Nitrate Therapy - A Decade
of Changing Concepts . . . . . . . . . . . . . . . . . . . . . . . . . .
17 Nitrate Therapy in Angina Pectoris . . . . . . . . . . . . . . . . .
. . . . . . . 23 Mononitrates . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 39 Transdermal
Administration of Nitrates . . . . . . . . . . . . . . . . . . . 53
Nitrates in Angina Pectoris - Rationale of Use and Avoidance of
Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Treatment of Congestive Heart Failure - Summary . . . . . . . .
