Bone marrow transplantation has emerged as a major form of treatment for
a broad range of human diseases. Marrow transplantation has many unique
biologic features and its principles differ markedly from the
transplantation of solid organs. This volume overviews the present
status of bone marrow transplantation and summarizes recent progress and
controversies. Ad- vances in defining the underlying biology of marrow
transplantation are discussed. The current status of several major
clinical problem areas are reviewed, including engraftment, acute and
chronic graft-versus-host dis- ease, immunodeficiency, and opportunistic
infections. The therapeutic role of allogeneic and autologous bone
marrow transplantation is discussed, and results are compared with
alternative therapies. lX List of contributors ANASETII, CLAUDIO, M. D.,
Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle,
Washington 98104 APPELBAUM, FRED, M. D., Fred Hutchinson Cancer Research
Center, 1124 Columbia Street, Seattle, Washington 98104 ARMITAGE, JAMES
0., M. D., Department of Internal Medicine, Univer- sity of Nebraska
Medical Center, 42nd and Dewey Avenue, Omaha, Nebraska 68105 BEATIY,
PATRICK G., M. D., Fred Hutchinson Cancer Research Center, 1124 Columbia
Street, Seattle, Washington 98104 BIERMAN, PHILIP J., M. D., Department
of Internal Medicine, Univer- sity of Nebraska Medical Center, 42nd and
Dewey Avenue, Omaha, Nebraska 68105 BUTTURINI, ANNA, M. D., Department
of Pediatrics, University of Parma School of Medicine, Parma, Italy
CHAMPLIN, RICHARD, M. D.
