This, the third volume of the Blood Cell Biochemistry series, follows
the pattern estab- lished in the two previous volumes by containing
up-to-date specialist reviews of topics of current interest within the
field of study defined by the subtitle. Thus, the topics included can be
loosely classified under the broad subtitle "Lymphocytes and
Granulocytes," but this does not indicate the full scope of content,
scientific interest, and emphasis of the present volume. The opening
chapter, by Antonio Bonati, surveys the currently available bio-
chemical, immunological, and molecular markers of hemopoietic precursor
cells. This is followed, appropriately, by a contribution from Arnold S.
Freedman on the cell surface markers in leukemia and lymphoma. In a
detailed chapter, Annette Schmitt-Graff and Giulio Gabbiani discuss the
cytoskeletal organization of normal and leukemic lympho- cytes and
lymphoblasts. John C. Cambier and his colleagues then present a
discussion of the signaling events in T-Iymphocyte-dependent
B-Iymphocyte activation. Lymphocyte IgE receptors and IgE-binding
factors are dealt with by Kwang-Myong Kim and his colleagues, and the
role ofgranule mediators in lymphocyte-mediated cytolysis is covered by
John Ding-E Young and his associates. A short contribution from James D.
Katz deals with the intricacies and difficulties of studies on the
complement C3b (CRl) receptor and its cytoskeletal interactions in
neutrophils. Arthur K. Sullivan then presents an in-depth survey of the
membrane biochemistry surrounding the flow of granule organelles in
leukocyte differentiation.