Antibacterial agents act against bacterial infection either by killing
the bacterium or by arresting its growth. They do this by targeting
bacterial DNA and its associated processes, attacking bacterial
metabolic processes including protein synthesis, or interfering with
bacterial cell wall synthesis and function.
Antibacterial Agents is an essential guide to this important class of
chemotherapeutic drugs. Compounds are organised according to their
target, which helps the reader understand the mechanism of action of
these drugs and how resistance can arise. The book uses an integrated
"lab-to-clinic" approach which covers drug discovery, source or
synthesis, mode of action, mechanisms of resistance, clinical aspects
(including links to current guidelines, significant drug interactions,
cautions and contraindications), prodrugs and future improvements.
Agents covered include:
- agents targeting DNA - quinolone, rifamycin, and nitroimidazole
antibacterial agents
- agents targeting metabolic processes - sulfonamide antibacterial
agents and trimethoprim
- agents targeting protein synthesis - aminoglycoside, macrolide and
tetracycline antibiotics, chloramphenicol, and oxazolidinones
- agents targeting cell wall synthesis - β-Lactam and glycopeptide
antibiotics, cycloserine, isonaizid, and daptomycin
Antibacterial Agents will find a place on the bookshelves of students
of pharmacy, pharmacology, pharmaceutical sciences, drug
design/discovery, and medicinal chemistry, and as a bench reference for
pharmacists and pharmaceutical researchers in academia and industry.
