In the last decade, ACE inhibitors have become a cornerstone of
cardiovascular drug therapy. Beneficial effects in patients with
hypertension, heart failure, and post myocardial infarction have been
established in large clinical trials. In parallel, ex- perimental
research has shifted the interest from the immediate homeostatic
function of the circulating renin-angiotensin-system to the multiple
paracrine functions of local tissue renin-angiotensin-systems, including
hypertrophy, hyperplasia, athe- oenesis, and vasomotion. . It was the
aim or a symposium held in Hamburg, October 22-24, 1992, to bring
together an international panel of experimental and clinical scientists
and to discuss the most recent findings on the role of angiotensin and
associated mediators in car- diovascular adaptation and disease, with a
particular emphasis on the treatment of such disease by ACE inhibitors.
The meeting and this publication were generously supported by Astra
Chemicals. H. Grobecker G. Heusch B. E. Strauer Contents Foreword. . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . V Introduction Local expression and
pathophysiological role of renin-angiotensin in the blood vessels and
heart Dzau, V. J. . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . 1 Myocardial
Perfusion Angiotensin, ACE-inhibitors and endothelial control of
vasomotor tone Luscher, T. F. . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Local and neurohumoral control of coronary blood flow Krajcar, M., G.
Heusch. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 25 ACE-inhibitors in coronary artery disease?
Vogt, M., W. Matz, B. E. Strauer . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 43 Myocardial Hypertrophy Molecular
mechanisms of cardiac gene expression Nadal-Ginard, B., V. Mahdavi . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65
Myocardial perfusion dependent and independent mechanisms of regional
myocardial dysfunction in hypertrophy Vatner, S. F., L. Hittinger . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
.
