Quality measurement, control, and improvement in combinatorial
chemistry
Combinatorial chemistry has developed rapidly in the past decade, with
great advances made by scientists working on analysis and purification
of a large number of compounds and the analysis of polymer-bound
compounds. However, formidable challenges lie ahead of today's
researcher. For example, high-throughput analysis and purification
technologies must be further developed to ensure combinatorial libraries
are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial
Chemistry describes various analytical techniques and systems for the
development, validation, quality control, purification, and
physicochemical testing of combinatorial libraries. A new volume in
Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and
optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of
libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification
stages
Drawing from the contributions of respected experts in combinatorial
chemistry, this comprehensive book provides coverage of applications of
Nuclear Magnetic Resonance (NMR), liquid chromatography/mass
spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar
electrokinetic chromatography (MEKC) technologies, as well as other
analytical techniques.
This eminently useful volume is an essential addition to the library of
students and researchers studying or working in analytical chemistry,
combinatorial chemistry, medicinal chemistry, organic chemistry,
biotechnology, biochemistry, or biophysics.
